I still have nothing to help with that at all. I’m glad that I found something to give me my life back, and that’s my hope for you. Objective: Fatigue affects more than 60% of multiple sclerosis (MS) patients and is one of the most troublesome symptoms of the disease. So sorry your going thru this, I was on it and stopped, it didn't help me. Maybe you could find a comprise. She still feels tired, but not so tired that she can't do anything. Evaluating the effects of amantadine, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis – result of a pilot randomized, blind study. JMWCO, it's Fancy1959. My neurologist has just changed me from Tecfidera to a new drug, Mayzent. I just not into severe headaches. The aim of our study was to compare efficacy of amantadine, modafinil and ALCAR with placebo in patients with MS. Was on Amantadine for 6 months prior to Provigil. Nourbakhsh B, et al. It is advisable to: (1) improve knowledge on the underlying mechanisms of MS-related fatigue; (2) achieve an agreement on accurate, reliable and responsive outcome measures of fatigue; (3) perform good quality RCTs. I was hoping that the amantadine would help with the fatigue and give me some focus. She says they go away after a while but what died that mean?!?! I do not find my fatigue any worse and it seems as if my muscle spasticity is getting a little bit better with each infusion. For Fatigue: “Two weeks ago, I began Amantadine for extreme fatigue from MS. I started forgetting to take the afternoon dose because I had so much energy that I didn’t need it, and I told my MD that. The mechanism of action in terms of how it specifically improves MS fatigue is still not e… I do better with more sleep. I just want to be able to wake up, feel energized enough to do daily tasks, play with my kids and get maybe 1 PROJECT off my to do list and I would think that's a win! I myself took this drug had headache but no help with fatigue. Now I just use coffee. My MD told me to take the second dose by noon. Can't find much info on the net about it. I have only been on Amantadine for about 2 weeks. Current treatment options for MS fatigue include amantadine, modafinil and acetyl-l-carnitine (ALCAR). 1,2 This condition has been reported worldwide, and case definitions have been developed by the Centers for Disease Control and Prevention. Anything that would give me migraine type headaches I would certainly talk to my doctor about and probably asked if I could get a different medicine or get off of it totally. It didn't work for me which is a shame because it was much less expensive than Provigil. Your imitations may be much more severe than mine, so we really can't compare, but if possible, talk to your doctor and ask about switching to Provigil or one of its generics. On amantadine 31% had marked improvement; 15.6% moderate improvement; 15.6% mild improvement; and 36.5%unchanged. Side effects were numerous both on amantadine and on placebo. Stopped amantadine that day. I had both motivation and focus on provigil. I think if i just had some basic work, personal projects like the groceries and taking care of the kids - id be good. For years and years I've been taking Amantadine for many years (~15 or more). Amantadine produced a small but statistically significant decrease in fatigue. There may be a perfectly good medical reason. I do not feel as if it works nearly as well as Modafinil, but I have to remember, it's only been 2 weeks. Sometimes We forget to tell them everything, or they're not listening, perhaps because we are not clear enough, or insistent enough or just plain don't make ourselves clear. Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to drug resistance. Waiting...waiting...more headaches . I still have my caffeine in the morning, but it’s less than it use to be, and a that’s work in progress. Amantadine acts directly on the central nervous system and helps stimulate the production of dopamine, a neurotransmitting chemical similar to adrenaline. I just want to sleep, FOCUS when I’m awake and feel good in those waking hours. It speeds up the absorption of the Mayzent by about twice. Conversations about support, research, drug therapies, nutrition, exercise, and more. Just wondering if anyone has used Amantadine for fatigue and how it worked for them? Any positive results for you? Discontinuation of naproxen leads to resolution of signs and symptoms. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. I KNOW i have more thank I should on my plate but all that continues to change as the year continues... more things drop off and I'M NOT REPLACING ANY OF THEM....LOL. I did that twice and that just made sleep wise but my focus amazing! has this happened to anyone else&what have you done,if there is anything? If you take amantadine within a few hour of going to bed it could lead to difficulty sleeping or vivid dreams. I did that twice and that just made sleep wise but my focus amazing! Enjoy the little one - they truly do grow up TOO FAST. This turned into a lack of focus and more fatigue and experimentation with some caffeine tablets (I barely drink soda/no coffee). I did! Different pharmacological and non-pharmacological methods have been used for treatment of this symptom in MS patients. Substantial evidence supporting their efficacy is however lacking. Food as medicine and other coping skills too. Thanks KDali. I just don't do anything, that is the only thing my ins. Individuals on death bed are sprinkled regarding "tulasi Water" by pouring a couple of declines into the mouth. I'm going to give that ago. The few times I've questioned whether or not it was helping and stopped it to see, I definitely noticed an increase in fatigue. It has been demonstrated that this medication, through some unknown mechanism, is sometimes effective in relieving fatigue in multiple sclerosis. For fatigue, one of the most prevalent subjective symptoms in MS patients, methylphenidate, modafinil, and amantadine are commonly prescribed. I started Ocrevus at the end of May 1st ½ injection and 2ns early June. I finally had someone explain that the headaches are like those that have daily coffee and go through withdrawl and get headaches. I didn’t have headaches with it, but the other drugs for fatigue gave me migraines. This makes the Mayzent less effective. There is one feature article on amantadine alone, ... Facebook Twitter Reddit Pinterest Tumblr WhatsApp Email Link. So she can go off of it for a couple weeks, the hop back on to get the effects back. I’ve been taking modafinil for a few years now, and have even recently moved up to the maximum dose of 400mg a day (200mg morning and early afternoon). I have had the same irritability effect on any CNS fatigue drug like modafinal, Adderall, ampyra. One of the more positive things to come up from my recent diagnosis is that this new Neuro is taking my chronic fatigue seriously. I've heard of others that have good luck with Ritalin. When you were on it did you notice any improvements?? F is a chronic and debilitating hallmark of the chronic fatigue syndrome, which is often accompanied by sleep disturbances, myalgias, and depression. Have not seen 9PM for months and that is with naps during the day. MSVIRTUAL2020, Abstract PS13.03. Many generic formulations of amantadine are available. It did help for a while but it didn’t do what I needed it to, even with caffeine. But you can’t live like that so neuro started me on amantadine and I’ve had some of the worst headaches daily. Still looking for the answer pam. Seems like docs have to try Amantadine first before they can prescribe, and get insurance approval, for Provigil. would approve. As many of us have mentioned, myself included, 90 days is the min for results but a year+ is better. 2013 ;115(Suppl 1): S86 – 89 . In this case it is building up the tolerance to the drug and have been asked to keep it up for another few weeks but reduce the dosage to help with the sleep issues. No need for the apology, I get it! Mostly just 1/2 pill but full pill if fatigue worsens, It's the only one I've tried and it works for me, Fall asleep on couch @ 9p up again at 10, asleep 11 awake 430a, I also take amantadine, my dr said 1 when awakening( I get up at 7am) and 1 at noon.I didn't have headaches and it works for me but a side effect is itching, he cut me back to one a day,which took away the itching but I do feel more fatigue again. ), does anyone have experience with it? I'm a little wary of anything that could be addictive. I find that I was 'tired' cause my life was 'tiring' which is why small MS signs were missed until the major relapse that led to the diagnosis. So talk to your doctor and assert yourself. Jul 19, 2014 #2. I don't sit down tho, I keep going. Amantadine, modafinil, and methylphenidate were not superior to placebo in improving multiple sclerosis fatigue and caused more frequent adverse events. Have family history with addictions. Hope it get's better for you. That's great. Amantadine is a treatment for Parkinson’s disease that can also be used to treat fatigue in patients with multiple sclerosis (MS). We haven't gotten to that point yet (I don't think), but it's nice to know it's an option. How do you like Provigil? Keep looking, it might be a combo of things that you just have not tried yet. All in all, these agents should not be used indiscriminately for the treatment of MS-related fatigue. When I did go to work, no one noticed how different I was or how much I was struggling. The doc said people can become used to the drug, and that cycling it can help. Patients dont need any more services beyond a daily dose of one of these drugs. Heard it may improve fatigue in MECFS . The pharmacist pamphlet had big bold letters DO NOT ABRUPTLY STOP TAKING. Was on Amantadine for 6 months prior to Provigil. So I’m waiting for them to advise. Forums. This turned into a lack of focus and more fatigue and experimentation with some caffeine tablets (I barely drink soda/no coffee). I think it would be easier if i had less obligations (working on it) and could just sit and say I can FOCUS on this for the next 60 minutes and take a break. It’s been a month since I’ve taken any and probably 2 or 3 since I’ve needed to take any. Having kids, work and personal obligations changes how much time you can devote to everything. Dopamine affects a structures in the brain collectively known as the basal ganglia, which help regulate movement, emotional response, and the ability to experience pleasure and pain. Fighting fatigue!Modafinil vs amantadine Hello all, like a lot of us one of my biggest struggles is with fatigue. Wondering if anyone has experience with this drug? I am taking both provigil, 200mg, 2 per day and 1 amantadine, 100mg and fatigue is still an issue. That’s why I asked about reducing the dose to once a day but no reply yet. The first day was like she was on speed. My neuro said it was an energy pill (not) but it does help me focus. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Under these circumstances, as fatigue develops, intracortical inhibitory circuits located within or upstream to M1 might be engaged in an opposite manner. Amantadine has an average rating of 9.4 out of 10 from a total of 5 ratings for the treatment of Chronic Fatigue Syndrome. SOC Senior Member. That's where i'm flustered. So I have had the strangest symptom, probably for around a year now, possibly more. Very depressing, it was like after having her, my fatigue and cog fog was on fast forward. 200mg at breakfast and another 100 at lunch. Fatigue may interfere with daily work and activities. It didn't work for me which is a shame because it was much less expensive than Provigil. On the good days, I get lots done and can do a lot and for that i'm grateful - it just isn't daily and I can't expect it to happen even when I want it. My neurologist has prescribed me amantadine for fatigue (I have M.S. 100% of those users who reviewed Amantadine reported a positive effect, while 0% reported a negative effect. I was given Modafinil (generic for Provogil). ☀️. First dose I felt excellent for two weeks then crappy for one month.
The channel itself is aIt seems that in the three months since I have been on Amantadine, Trihexphenidyl and Azilect for Parkensons, I have lost considerable weight(16 lbs).. It was humorous in an alarming kind of way. It acts as a nicotinic antagonist and noncompetitive NMDA antagonist. I’m hopeful as things keep changing and I’m further in my Ocrevus dosing it’ll keep getting better as everyone on the forum predominantly tend to have good reactions the longer they are on it. Here's to another good day for you and all the perks of 6th month crazy infusions! Has anyone had that happen? It was 9am/9pm for my twice a day but I had to adjust he second or sleep was really difficult. My fatigue has gotten butter but my new normal had me passing out at 9 not able to help put the kids to bed and feeling like 8/9 hours asleep was never enough. I think irritated is probably my … I do know what you mean. Both kept me awake at night. Substantial evidence supporting their efficacy is lacking, however. Clin Neurol Neurosurg. In in my month of crappy and hoping that it ends soon. I probably wouldn’t have failed any real tests either. Someone along the way had also said that sometimes it may increase libido in women???? Summary. P.s. According to my "cognitive tests" i should have no issues but as the dr. said they are in a controlled environment which isn't real life. Amandatine for fatigue; anyone else on this? Anyone else out there dealing with this? Sadly I’m seeing past 9 too often and wouldn’t mind going back to passing out by 9, Thanks...I’ll see what the dr says - hopefully they’ll get back to me Monday. Just projects/work doesn't always give you more time. In this study, the effect of ondansetron and amantadine in the treatment of fatigue was compared. Notably, amantadine restored these adapting changes close to the level of those observed in control subjects (Figure 3) (see later in the discussion). New comments cannot be posted and votes cannot be cast, More posts from the MultipleSclerosis community. I'm not trying to get a high off it. After that she settled down. In the randomised crossover TRIUMPHANT-MS trial, none of these 3 agents was superior to placebo in improving MS-related fatigue, but they did cause more adverse … I'm hoping to figure out if i need it or not. … Amantadine is generally well tolerated with mild side effects. Side effects can include a dry mouth, constipation, nausea, anxiety and hyperactivity. I was sprung out of my head as I barely drink soda (i'm a 4-6 oz as needed for a pick me up) so it was a lot for me. I was taking it for a while. Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting their efficacy is sparse and conflicting. At last someone who does not think that it cant be a problem as I am retired! Columnist Laura Kolaczkowski is caught up in a situation in which her insurance provider wants to switch MS fatigue medication from modafinil to amantadine. If he won't change you to a more effective med, ask WHY. Randomized, placebo-controlled, crossover, 4-sequence, 4-period, double-blind (participants and investigators), multicenter trial of 3 commonly used medications for treatment of MS-related fatigue (amantadine, modafinil, methylphenidate) versus placebo in fatigued subjects with MS defined by McDonald Criteria. Methods I am have never been on Amandatine so I am really not very much help to you with this question. For the most part I am doing well (80% of the time).. i just want to keep scratching things off the list and know that when I wake up i'll do more than just feel like falling asleep. In all 3 active intervention groups, a higher percentage of participants reported adverse events: 38.6%, 40.0%, and 39.5% while taking amantadine, modafinil, and methylphenidate, respectively. Well yes - this forum and MS Websites..but it is nice to have the added guidance from someone that specializes in this. Focusing on issues facing people with MS and their family and friends. Ultimately, you take 100 mg when you wake up and then 4 hours later another 100mg or what you need based on your level of sleep. Searched the forum and didn’t see much about amantadine that’s current. Hello, anyone else in a similar situation. Patients ought to likewise be motivated to read the NSAID Medication Guide that accompanies each prescribed gave. I take it in the morning but can easily nap/sleep. Modafinil was the one I was taking - I call it "the Poor Man's" Provigil. Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. YMMV. Amantadine is an antiviral medication used to prevent or treat certain influenza infections; it is also given as an adjunct for the treatment of Parkinson's disease. My doctor recently prescribed amantadine for my MS fatigue. I do not believe the Ocrevus causes me any additional fatigue. Jul 19, 2014. I know I have been forcing myself to do more, and a million times a day I feel I HAVE to sit down. Looks like you're using new Reddit on an old browser. When EC-Naprosyn was provided as a single dose with antacid (54 mEq buffering capability), the top plasma levels of naproxen were unchanged, but the moment to peak was lessened (indicate Tmax fasted 5.6 hours, suggest Tmax with antacid 5 hrs), although not considerably. In October I will receive my second full dose of ocrevus so that will be my one year anniversary of being on ocrevus. No words. Thanks! My wife has been on Amantadine for a couple of months now. What did you end up doing if it didn’t work? Our goal was to compare the efficacy of these three medications with each other and placebo in patients with multiple sclerosis fatigue. I found I have to take the 2nd dose by 3pm or I can’t sleep. Amantadine Therapy for Fatigue in Multiple Sclerosis T.J. Murray ABSTRACT: We carried out a double blind control study of fatigue in 32 patients with multiple sclerosis, comparing amantadine hydrochloride 100 mg twice a day and placebo. That sounds horrible. Initially, pain increased all over, but it was explained to me that that was most likely from a return to moderate activity. Thanks! She wants to know why. I continued treatment and have noticed a marked improvement of cognitive functioning, ability to maintain focus and recall events with more ease. I haven't gotten a response yet..but seriously... i'm not sure if this is helping if i'm doing OK without it just crashing out by 9... it's not a bad thing to crash by 9.. i just can't stay focused the next day cause I just feel warn/fatigued. I wrote my neuro asking if i should just take it 1x a day instead of twice. I currently use ethylphenidate when I literally can't get out of bed. But you can’t live like that so neuro started me on amantadine and I’ve had some of the worst headaches daily. We have enough other issues to deal with then to bring our heads functioning at very low norm with a migraine.. The efficacy of amantadine in reducing fatigue in people with MS is poorly documented, as well as its tolerability. I hope you find a dose that works for you! Fatigue may be an incapacitating feature of this illness.Amantadine has been found to be beneficial in the fatigue of multiple sclerosis.1,2 The basis for this is uncertain. An important placebo effect was noted. 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